slow aging

Unlocking the Fountain of Youth: How Proper Calcium Signaling in Immune Cells Can Slow Aging

Published On: July 26, 2023By Tags: ,

Recent research from the University of Virginia School of Medicine has shed light on a crucial mechanism of aging. It involves improper calcium signaling in immune cell mitochondria, leading to chronic inflammation and accelerating the aging process. This discovery provides valuable insights into the aging process. Moreover, it paves the way for potential therapeutic strategies to combat age-related inflammation, potentially mitigating cardiometabolic and neurodegenerative diseases. The question arises: Can we slow aging?

The Impact of Aging on Mitochondria

As we age, our immune cell mitochondria, specifically macrophages, experience a decline in their ability to process calcium efficiently. Furthermore, chronic inflammation, which plays a pivotal role in age-related health conditions, links to this reduction in calcium uptake.

The Key Findings

Researchers, led by Bimal N. Desai, PhD, at UVA Health, have identified a keystone mechanism responsible for age-related changes in macrophages. Notably, they found that these immune cells become more prone to chronic, low-grade inflammation over time. Moreover, when exposed to an invader or tissue damage, they become hyperactive, driving a process called “inflammaging” – a chronic inflammation that accelerates aging.

The Promise of Increasing Calcium Uptake

Addressing this age-related inflammation through calcium supplementation is not as straightforward as it may seem. The root of the problem lies in the macrophages’ inability to use calcium effectively. However, the research team’s breakthrough has pinpointed the precise molecular machinery involved in this process, thus opening up opportunities to discover ways to stimulate this machinery in aging cells.

Potential Therapeutic Strategies

In terms of potential therapeutic strategies, targeting tissue-resident macrophages with suitable drugs may present new avenues to slow age-associated neurodegenerative diseases. Moreover, the researchers speculate that their discovery may extend beyond macrophages. Thus, it could potentially benefit other related immune cells generated in the bone marrow, ultimately bolstering the immune system’s effectiveness in old age.

Publication and Funding

The team’s findings have been published in the scientific journal Nature Aging. It’s worth noting that the research was made possible through the support of the National Institutes of Health and the Owens Family Foundation.


Unraveling the link between calcium signaling in immune cell mitochondria and age-related inflammation represents a monumental leap in understanding the molecular basis of aging. Armed with this knowledge, researchers now have the potential to develop novel interventions. These interventions may hold the key to healthier, longer lives. And they may provide hope for preventing age-related conditions that have plagued humanity for generations. By tapping into the intricate mechanisms governing inflammation, we may unlock the secrets to the fountain of youth. This will result in ultimately slowing aging, and changing the trajectory of aging-related diseases.


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